Preparation and characterization of indomethacin/poly(N-isopropylacrylamide)-beta-cyclodextrin complex with temperature-sensitivity.
- Author:
Yun XIA
1
;
Li-yan QIU
;
Yi JIN
Author Information
- Publication Type:Journal Article
- MeSH: Acrylic Resins; chemistry; Delayed-Action Preparations; chemistry; Drug Carriers; Indomethacin; administration & dosage; chemistry; Temperature; beta-Cyclodextrins; chemistry
- From: Acta Pharmaceutica Sinica 2005;40(2):187-192
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo synthesize poly(N-isopropylacrylamide)/cyclodextrin conjugate (PNIPA-beta-CD) as thermosensitive drug carrier, incorporate indomethacin into the conjugate and evaluate the drug release from the carrier in vitro.
METHODSPNIPA-beta-CD was synthesized by introducing carboxyl terminated PNIPA into the primary hydroxy group of beta-CD. The obtained conjugate was characterized by FTIR, 1H NMR and DSC. The indomethacin/PNIPA-beta-CD complex was prepared by lyophilization. In vitro drug release from the complex was carried out at 25 degrees C and 37 degrees C respectively.
RESULTSThermosensitive PNIPA-beta-CD was synthesized successfully. The LCST is 35 degrees C, as measured by turbidity method. The drug release from indomethacin/PNIPA-beta-CD complex was slower at 37 degrees C than that at 25 degrees C.
CONCLUSIONThermosensitive PNIPA-beta-CD with molecular inclusion capacity is a potential carrier for drug sustained release.
