Excretion of beta-elemene from rat respiratory tracts.
- Author:
Kun WANG
1
;
Zhi LI
;
Yu-ren CHEN
;
Xiu-ying WU
;
Shu-yuan LI
;
Cheng-ye SU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Chromatography, Gas; Curcuma; chemistry; Infusions, Parenteral; Injections, Intravenous; Male; Plants, Medicinal; chemistry; Rats; Rats, Sprague-Dawley; Respiratory System; metabolism; Sesquiterpenes; administration & dosage; isolation & purification; pharmacokinetics
- From: Acta Pharmaceutica Sinica 2005;40(1):54-56
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo investigate the excretion of beta-elemene from the respiratory tracts in male Spraque-Dawley rats.
METHODSAfter a single administration of beta-elemene to rats at the dosage of 75 mg x kg(-1) (i.v. or i.p.), the exhaled gases were collected and concentrated at various time points. The residues were analyzed by gas chromatography.
RESULTSA minor amount of unchanged beta-elemene was excreted via rat respiratory tracts after iv and ip administration of a single dose. The cumulative excretion were 1.41% and 0.51% respectively.
CONCLUSIONThe results demonstrated that unchanged beta-elemene excretes from rat respiratory tracts, but may not be the main elimination pathway in rats.
