ZnPP IX and L-NAME reduce the cGMP content in the penile tissue of rats.
- Author:
Hong-Bin MA
1
;
Wen-bo QIN
;
Shi-liang GUI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Carbon Monoxide; antagonists & inhibitors; metabolism; Cyclic GMP; metabolism; Male; NG-Nitroarginine Methyl Ester; pharmacology; Nitric Oxide; antagonists & inhibitors; metabolism; Penis; drug effects; metabolism; Protoporphyrins; pharmacology; Rats; Rats, Wistar
- From: National Journal of Andrology 2009;15(6):523-525
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of CO release inhibitor zinc protoporphyria IX (ZnPP IX) and NO release inhibitor L-NAME on the content of cGMP in the penile tissue of rats.
METHODSThirty Wistar rats were randomly divided into a normal control, a ZnPP IX, and an L-NAME group, given saline (1 ml/kg/d), ZnPP IX (45 micromol/kg/d) and L-NAME (50 mg/kg/d), respectively, for 7 days. Then all the rats were killed, homogenate made from their penile tissues and detected for the contents of NOS, NO, CO and cGMP.
RESULTSThe contents of CO, NOS, NO and cGMP were all reduced in both the ZnPP IX and L-NAME groups as compared with the control group (P < 0.05).
CONCLUSIONZnPP IX and L-NAME can reduce the concentrations of CO and NO in the penile tissues of rats, and consequently the content of cGMP.
