Use triple marker screening from maternal serum: alpha-feto protein (AFP), beta-human chorionic gonadotropin (b-HCG) and conjugated estriol (UE3) to identify the fetus with aneuploidy and neural tube defect
- Author:
Thuy Trong Do
- Publication Type:Journal Article
- Keywords:
fetus
- MeSH:
Fetus;
Neural Tube Defects;
Aneuploidy
- From:Journal of Medical Research
2002;20(4):1-7
- CountryViet Nam
- Language:Vietnamese
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Abstract:
In this study, serum samples collected from 48 high-risk pregnant women were screened for three markers: alpha-feto protein (AFP), beta-human chorionic gonadotropin (b-HCG) and conjugated estriol (UE3) to define the risk of congenital aneuploidy and neural tube defect...The result showed the serum AFP level raised in two cases (more than 2.5MoM - Multiple of Median). One case has decrease in AFP (less than 0.06MoM) combined with decrease in UE3. Once has decrease in AFP (less than 0.06mOM) combined with increase in b-HCG. One case has decrease in AFP (less than 0.06MoM) combined with decrease in UE3 and increase in b-HCG level. One case has decrease in AFP alone (less than 0.06MoM). Fetal neural tube defect was identified in one case. Other four cases have increase in b-HCG only. these pregnancies should be referred to genetic study and further tests.
