Effects of heroin and purine nucleotide compensation on neutral alpha-glucosidase in rat epididymides.
- Author:
Jia-yue CUI
1
;
Jia-ying ZHANG
;
Wen-jing ZUO
;
Zhong-shan WANG
;
Min HONG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Epididymis; chemistry; Heroin; adverse effects; Heroin Dependence; metabolism; Male; Purine Nucleotides; pharmacology; Rats; Rats, Wistar; alpha-Glucosidases; metabolism
- From: National Journal of Andrology 2009;15(9):775-778
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the changes of neutral alpha-glucoside activity in the epididymis of heroin-dependent and heroin-withdrawal rats, and to investigate the effects of intervention with purine nucleotide (AMP and GMP).
METHODSEighty Wistar rats were randomly divided into 8 groups of equal number, control, nucleotide, heroin, heroin + nucleotide, 3 d withdrawal, 9 d withdrawal, 3 d nucleotide (nucleotide administrated for 3 days after heroin withdrawal) and 9 d nucleotide (nucleotide administrated for 9 days after heroin withdrawal). Neutral alpha-glucosidase activity in the epididymis was detected in each group of rats.
RESULTSCompared with the control group, neutral alpha-glucoside activity was markedly decreased in the heroin group (P < 0.05), and also in the 3 d and 9 d withdrawal groups, although with no significant differences (P > 0.05).
CONCLUSIONHeroin reduces neutral alpha-glucoside activity in the epididymis of rats, and this effect may continue for some time after drug withdrawal, while purine nucleotide can keep neutral alpha-glucosidase activity in a relatively stable state.
