Update of asthenospermia-related genes and proteins.
- Author:
Qi-zhao ZHOU
1
;
Chun-qiong FENG
;
Xiang-ming MAO
Author Information
1. Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China. zhou1224@fimmu.com
- Publication Type:Journal Article
- MeSH:
A Kinase Anchor Proteins;
genetics;
Animals;
Asthenozoospermia;
genetics;
metabolism;
Cytoskeletal Proteins;
genetics;
DNA Methylation;
genetics;
GTP Phosphohydrolases;
genetics;
Humans;
Male;
Mutation;
Septins
- From:
National Journal of Andrology
2009;15(9):836-839
- CountryChina
- Language:Chinese
-
Abstract:
One of the most common causes of male infertility is asthenospermia, whose pathogenesis, however, is not yet clear. Recent researches have found that some genes (such as tektin-2, DNAI1, DNAH5, DNAH11, AKAP4, SEPT4 and Smcp) and proteins (such as sperm proteins ACTB, ANXA5, PRM1, PRM2 and SABP and seminal proteins Tf, PSA, PAP and Fractalkine) are associated with asthenospermia. The finding of these molecular markers has provided a base for the explanation of the molecular mechanism of asthenospermia, and these markers may become the diagnostic and therapeutic targets of the disease.
