Expressions of eNOS and cytochrome P450 in the testis of sexually mature SD rats and their significance.
- Author:
Ya-ping REN
1
;
Li SUN
;
Xiao-yun SHAO
;
Jun CHEN
;
Bin XIONG
;
Lin-lin NONG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Aromatase; metabolism; Male; Nitric Oxide Synthase Type III; metabolism; Rats; Rats, Sprague-Dawley; Sexual Maturation; Testis; metabolism
- From: National Journal of Andrology 2009;15(10):911-914
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the expressions of endothelial nitric oxide synthase (eNOS) and cytochrome P450 (aromatase) in the testis of sexually mature male SD rats and their significance.
METHODSEighteen male SD rats, 6 five-week, 6 seven-week and 6 ten-week old, were selected for this study. Paraffin sections of the left testis were made and the expressions of eNOS and P450 observed by the immunohistochemical ABC method.
RESULTSPositive expressions of eNOS and P450 were found to be + + +, + and + + in the Leydig cells of the five-week, seven-week and ten-week old rats, respectively, and they were also observed in a few spermatocytes, though with no regularity.
CONCLUSIONIn the Leydig cells of sexually mature male SD rats, eNOS and P450 are differently expressed in different stages of sexual maturation, and they are correlated as well.
