The GATA family in reproduction.
- Author:
Cai-xia JING
1
;
Jia-zhou YANG
;
Qing-yan AI
;
Nai-zhou MIAO
;
Yu-feng ZHAO
;
Yan-mei WANG
Author Information
1. Department of Parasitology, West China School of Preclinical and Forensic Medicine, Sichuan University, Cheng-du, Sichuan 610041, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Chickens;
Female;
GATA4 Transcription Factor;
metabolism;
GATA6 Transcription Factor;
metabolism;
Humans;
Male;
Mice;
Ovary;
embryology;
Reproduction;
Swine;
Testis;
embryology;
Transcription Factors;
classification
- From:
National Journal of Andrology
2009;15(10):932-936
- CountryChina
- Language:Chinese
-
Abstract:
The GATA family proteins are a group of zinc finger transcription factors that are expressed in human and mammalian animals and play an important role in mammalian organ morphogenesis, cell proliferation and sex differentiation. GATA-4 and GATA-6 have been identified in the ovaries and testes of humans, mice, pigs and chickens. GATA-4 contributes to fetal male gonadal development by regulating the genes that mediate Müllerian duct regression and the onset of testosterone production. GATA-4 and GATA-6 are localized in and regulate the function of the ovarian and testicular somatic cells of fetal mice, especially granulosa cells, thecal cells, Sertoli cells and Leydig cells. GATA-4 is also present in the germ cells of fetal and prepubertal mice.
