Study on the association between 5, 10-methylenetrahydrofolate reductase C677T polymorphism and acute lymphoblastic leukemia risk: a Meta-analysis
10.3760/cma.j.issn.0254-6450.2011.10.018
- VernacularTitle:5,10-亚甲基四氢叶酸还原酶C677T基因多态性与急性淋巴细胞白血病易感性关系的Meta分析
- Author:
Xiao-Lei LI
1
;
Feng YU
;
Yong ZHANG
;
Jin-Chun QIU
;
Si-Ting LIU
;
Qing-Chuan LIAO
Author Information
1. 中国药科大学
- Keywords:
Acute lymphoblastic leukemia;
5,10-methylenetrahydrofolate reductase;
Gene polymorphism;
Meta-analysis
- From:
Chinese Journal of Epidemiology
2011;32(10):1030-1036
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the association between polymorphism of 5,10-methylenetrahydrofolate reductase C677T and risk of acute lymphoblastic leukemia (ALL).Methods Electronic search strategy was carried out among the databases from home and abroad to collect qualified research papers,according to the inclusion and exclusion criteria.Data on case-control studies on association between MTHFR C677T polymorphism and susceptibility to ALL were colleted and analyzed by models of TT vs.CC + CT or TT vs.CC through Meta-analysis.Stratified analysis was carried out according to different age groups (children or adult).Results In systematical analysis,the pooled odds ratios of MTHFR C677T genetype TT vs.CC + CT or TT vs.CC were 0.87(0.69-1.09 ) and 0.82 ( 0.63-1.06 ) respectively; in children' s group,the pooled odds ratios of MTHFR C677T genetype TT vs.CC + CT or TT vs.CC were 0.92 ( 0.79-1.08),0.88 ( 0.75-1.05 ) while in adult group,the pooled odds ratios of MTHFR C677T genetype TT vs.CC + CT or TT vs.CC were 0.45(0.26-0.77),and 0.41 (0.22-0.72) respectively.Conclusion The MTHFR gene 677T variant might not be associated with the risk of children's ALL but might be associated with a reduced risk on adult's ALL.
