Expression of Tumor Metastasis Related Genes in Korean Colorectal Cancers and Cell lines.
- Author:
Ok Suk BAE
;
Seong Il SUH
;
So Young CHUN
- Publication Type:Original Article
- Keywords:
Colorectal cancer;
CD44v;
MMP-7;
E-cadherin
- MeSH:
Cadherins;
Cell Line*;
Colorectal Neoplasms*;
Humans;
Mucous Membrane;
Neoplasm Metastasis*
- From:Journal of the Korean Society of Coloproctology
1998;14(1):11-19
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We studied the expressions of E-cadherin, MMP-7 and CD44V in colorectal cancer and their corresponding normal mucosa using RT-PCR. From the 26 patients whom a com parative study of clinical and histopathological data is available, MMP-7 and CD44V were significantly enhanced in cancer and their metastatic tissues, compared with their normal mucosa. E-cadherin did not reveal any difference between cancer and normal mucosa. The relashionship between these genes and colorectal cancer development can not be confirmed by this study, however CD44v and MMP-7 may be associated with metastasis of colorectal cancer.
