Advances in mechanisms of treatment for spinal cord injury with lithium.
- Author:
Zhang DUO
;
Xi-jing HE
- Publication Type:Journal Article
- MeSH:
Animals;
Apoptosis;
drug effects;
Humans;
Lithium;
therapeutic use;
Neurons;
cytology;
drug effects;
Spinal Cord Injuries;
drug therapy;
physiopathology
- From:
China Journal of Orthopaedics and Traumatology
2015;28(7):679-682
- CountryChina
- Language:Chinese
-
Abstract:
Spinal cord injury is a serious disabling disease caused by a series of internal and external factors in the field of orthopaedics and neuroscience, which is a big problem for doctors all over the world. Lithium has been used to treat dipolar disorder for over 100 years. It has been reported that lithium is benefit for brain neuron. The treatment effect for spinal cord injury gets more and more attention. Researches indicate that lithium is benefit for spinal cord injury by protecting neuron,reducing after-injury inflammation increasing the produce and release of neurotrophins, stimulating neurogenesis, enhancing autophagy and inhibiting apoptosis. This article summaries advances in mechanism of treatment for spinal cord injury with lithium by reviewing and analyzing researches. Therapy combined with lithium has a good application prospect.
