Experimental study on cardiac protection and anti-oxidation effects of jisheng injection.
- Author:
Su-qing ZHANG
1
;
Xue-jun SHI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antioxidants; pharmacology; Drugs, Chinese Herbal; pharmacology; Heart; Male; Organ Preservation; Organ Preservation Solutions; pharmacology; Rats; Rats, Wistar; Reishi; chemistry; Superoxide Dismutase; metabolism
- From: Chinese Journal of Integrated Traditional and Western Medicine 2003;23(6):455-457
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of Jisheng injection (JSI) in protecting heart.
METHODSIsolated heart of rat was preserved in modified Euro-Collins solution (mEC) containing JSI for 20 hrs, and that preserved in simple mEC was taken as control. Then Langendorff isolated rat heart perfusion was conducted. Forty minutes after perfusion, the cardiac function, coronary flow, myocardial water content were determined, and lactate dehydrogenase (LDH), creatine kinase (CK) activity in perfusate, superoxide dismutase (SOD) activity, malondialdehyde (MDA) content in myocardial tissue and pathologic change in myocardium were also observed.
RESULTSThe cardiac function and coronary flow of isolated heart preserved in JSI containing mEC was significantly better than those in the control (P < 0.01), with the LDH, CK activity and MDA content significantly lower (P < 0.01 and P < 0.05), SOD activity significantly higher (P < 0.05) and pathologic injury milder than those in control, but comparison of cardiac water content between the two groups showed insignificant difference.
CONCLUSIONJSI has good cardiac protective and anti-oxidizing effects.
