Effect of pingchuan mixture on eosinophil cation protein and interleukin-5 in experimental guinea pigs with asthma.
- Author:
Xiang-ming FANG
1
;
Shi-hong CAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Asthma; chemically induced; metabolism; Blood Proteins; metabolism; Bronchoalveolar Lavage Fluid; chemistry; Drugs, Chinese Herbal; pharmacology; Eosinophil Granule Proteins; Eosinophils; metabolism; Guinea Pigs; Interleukin-5; metabolism; Ovalbumin; Ribonucleases; metabolism
- From: Chinese Journal of Integrated Traditional and Western Medicine 2003;23(8):609-611
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of Pingchuan Mixture (PCM) on plasma eosinophil cation protein (ECP), interleukin-5 in bronchial alveolar lavage fluid (BALF) and inflammatory cell count in experimental guinea pigs with asthma.
METHODSThe eosinophil, neutrophil, lymphocyte count were conducted by conventional method, IL-5 was detected by ELISA and ECP determined by RIA.
RESULTSLevels of eosinophil, neutrophil, lymphocyte, ECP and IL-5 after treatment were significantly lower than those before treatment, the difference between groups treated respectively by PCM, aminophylline, dexamethasone and Dingchuan Zhike Tablet was insignificant.
CONCLUSIONPCM could treat asthma by reducing the inflammatory cell count, ECP and IL-5.
