Preventive and treatment effect of composite Rhodiolae on acute lung injury in patients with severe pulmonary hypertension during extracorporeal circulation.
- Author:
Ke-jin XU
1
;
Shi-fan ZHANG
;
Qing-xin LI
Author Information
- Publication Type:Clinical Trial
- MeSH: Adolescent; Adult; Cardiopulmonary Bypass; adverse effects; Child; Child, Preschool; Drugs, Chinese Herbal; therapeutic use; Female; Heart Septal Defects, Ventricular; complications; drug therapy; surgery; Humans; Hypertension, Pulmonary; complications; drug therapy; Infant; Male; Middle Aged; Phytotherapy; Postoperative Complications; prevention & control; Respiratory Distress Syndrome, Adult; etiology; prevention & control; Rhodiola
- From: Chinese Journal of Integrated Traditional and Western Medicine 2003;23(9):648-650
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the possibility of early prevention and treatment of acute lung injury by using composite Rhodiolae (CR) in patients with severe pulmonary hypertension during extracorporeal circulation.
METHODSSeventy-six patients with severe pulmonary hypertension screened out by color 2D-Doppler ultrasonography were randomly divided into the treated group (n = 40) and the control group (n = 36). The general treatment for the two groups, including preoperational preparation, operational procedure and conventional drug therapy, was the same. To the treated group, CR was administered 4 g every day (half the dose in children) at 7-10 day before and 5-7 day after the operation. The life signs, pulmonary ventilation parameters, arterial blood gas analysis were monitored and blood levels of TXB2, 6-keto-PGF1 alpha in both groups were determined in the fixed time points.
RESULTSThe various parameters in the treated group were all better than those in the control group (P < 0.05 or P < 0.01), the occurrence rate of acute lung injury and its mortality in the treated group were 7.5% (3/40) and 0% (0/3) respectively, while in the control group were 19.4% (7/36) and 43% (3/7) respectively.
CONCLUSIONCR has good preventive and treatment effect in treating complicated acute lung injury during extracorporeal circulation (cardiopulmonary bypass) in patients with pulmonary hypertension.
