Effect of dihydro-qinghaosu on auto-antibody production, TNF alpha secretion and pathologic change of lupus nephritis in BXSB mice.
- Author:
Yan-jun DONG
1
;
Wei-dong LI
;
You-you TU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antibodies, Antinuclear; blood; Artemisinins; pharmacology; Immunosuppressive Agents; pharmacology; Lupus Erythematosus, Systemic; immunology; pathology; Lupus Nephritis; pathology; Male; Mice; Mice, Inbred Strains; Random Allocation; Sesquiterpenes; pharmacology; Tumor Necrosis Factor-alpha; secretion
- From: Chinese Journal of Integrated Traditional and Western Medicine 2003;23(9):676-679
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of dihydro-qinghaosu (DQHS) on auto-antibody production, TNF alpha secretion and pathologic change of lupus nephritis in BXSB mice and the possible mechanism of DQHS in treating systemic lupus erythematosus (SLE).
METHODSAnti ds-DNA antibody and TNF alpha in serum of the BXSB mice were detected by enzyme linked immunosorbent assay (ELISA). Renal tissue was stained by HE and Masson.
RESULTSIn the height and moderate dose DQHS groups, as compared with the model group, levels of anti-ds-DNA antibody and serum TNF alpha were significantly lower (P < 0.05); and renal pathological change was milder.
CONCLUSIONDQHS could inhibit the production of anti-ds-DNA antibody and secretion of TNF alpha and improve the pathologic lesion of lupus nephritis in BXSB mice.
