Effects of langchuangjing granule on apoptotic of CD4+ T and CD19+ B in spleen of BXSB mice with systemic lupus erythematosus.
- Author:
Xi-de LIU
1
;
Shi JIN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antigens, CD19; analysis; Apoptosis; drug effects; B-Lymphocytes; pathology; CD4-Positive T-Lymphocytes; pathology; Drugs, Chinese Herbal; pharmacology; Female; Lupus Erythematosus, Systemic; immunology; pathology; Male; Mice; Mice, Inbred Strains; Random Allocation; Spleen; pathology
- From: Chinese Journal of Integrated Traditional and Western Medicine 2003;23(9):692-694
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect on apoptotic of CD4+ T, CD19+ B in spleen of BXSB mice with systemic lupus erythematosus treated with Langchuangjing Granule and to probe into the mechanism of treatment.
METHODSThe apoptosis was examined by the flow cytometric analysis and immunofluorescence double-staining method.
RESULTSApoptosis of male BXSB mice speeds up. Langchuangjing Granule can restrain the excessive apoptosis of CD4+ T and CD19+ B cells in spleen.
CONCLUSIONLangchuangjing Granule treated systemic lupus erythematosus by restraining the excessive apoptotic of T, B lymphocytes, probably restraining the release of excessive amount of apoptotic DNA fragments, so decreasing abnormal proliferation of B cells and the produce of autoantibodies.
