Clinical observation on treatment of aplastic anemia patients by zaizhang decoction combined with Western medicine.
- Author:
Xiao GUO
1
;
Mei ZHANG
;
Yi-xin ZHANG
Author Information
- Publication Type:Clinical Trial
- MeSH: Adolescent; Adult; Anemia, Aplastic; drug therapy; immunology; CD4-CD8 Ratio; Drug Therapy, Combination; Drugs, Chinese Herbal; therapeutic use; Female; Humans; Interleukin-2; blood; Male; Middle Aged; Phytotherapy; Tumor Necrosis Factor-alpha; metabolism
- From: Chinese Journal of Integrated Traditional and Western Medicine 2003;23(10):730-732
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of Composite Zaizhang decoction (ZZD) on immune function of chronic aplastic anemia (CAA) patients.
METHODSTo determine the levels of T-lymphocyte subset, serum tumor necrosis factor (TNF-alpha) and interleukin-2 (IL-2) in CAA patients before and after treatment, and to analyse the regulation of their changes comparatively with the group treated with conventional treatment and a normal control group.
RESULTSBefore treatment, CD4 was lower, CD8 higher, CD4/CD8 ratio also lower, TNF-alpha and IL-2 were higher in the ZZD treated group than those in the normal control group, with significant difference (P < 0.05), but after ZZD treatment, these indexes were all inversely changed, as compared with those before treatment and with those in the control group, the difference was significant (P < 0.05).
CONCLUSIONZZD might relieve the hemopoietic inhibition so as to promote the recovery of hemopoietic function through improving the T-lymphocyte subset and reducing the release of hemopoietic negative ragulatory factors such as TNF-alpha and IL-2 etc.
