Effect of shenfu injection on recovery of intestinal function, cellular immunity, serum interleukin-2 and tumor necrosis factor-alpha in children with intestinal obstruction after operation.
- Author:
Li-ya WANG
1
;
Ying-fei WEI
;
Hui-lan DU
Author Information
- Publication Type:Clinical Trial
- MeSH: CD4-CD8 Ratio; Child, Preschool; Drug Therapy, Combination; Drugs, Chinese Herbal; therapeutic use; Female; Gastrointestinal Motility; drug effects; Humans; Immunity, Cellular; Infant; Interleukin-2; blood; Intestinal Obstruction; drug therapy; immunology; physiopathology; surgery; Male; Phytotherapy; Postoperative Period; Recovery of Function; Tumor Necrosis Factor-alpha; metabolism
- From: Chinese Journal of Integrated Traditional and Western Medicine 2003;23(10):744-746
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of Shenfu injection (SFI) on recovery of intestinal function, T-lymphocyte subsets (CD4, CD8 and CD4/CD8), interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-alpha) in children with intestinal obstruction after surgical operation.
METHODSNinety-eight children suffering from intestinal obstruction after emergent surgical operation were divided into the SFI group (n = 50, treated with SFI after operation) and the control group (n = 48, treated with surgical operation alone). The intestinal function recovery rate (IFRR), T-lymphocyte subsets, serum levels of IL-2 and TNF-alpha in them were observed.
RESULTSAfter being treated for 7 days, the IFRR in the SFI group was 84.0%, which was significantly higher than that in the control group (62.5%, P < 0.05). CD4, CD4/CD8 levels increased in the SFI group after treatment (P < 0.05), while in the control group, CD8 increased significantly after treatment (P < 0.05) and higher than that in SFI group (P < 0.01). IL-2 level was much higher in the SFI group after treatment than that in the control group (P < 0.05). TNF-alpha level significantly lowered in both groups (P < 0.01), and the level in the SFI group was lower than that in the control group (P < 0.05).
CONCLUSIONSFI could promote the recovery of intestinal function, improve and regulate the immune function of the children after operation for intestinal obstruction.
