Effect of xuezhikang on blood lipids, serum oxidized low density lipoprotein, C-reactive protein and fibrinogen in patients with unstable angina pectoris.
- Author:
Qing-hai YAO
1
;
Chang-cong CUI
;
Jun-kui WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Angina, Unstable; blood; complications; drug therapy; C-Reactive Protein; metabolism; Cholesterol; blood; Drugs, Chinese Herbal; therapeutic use; Female; Fibrinogen; metabolism; Follow-Up Studies; Humans; Hyperlipidemias; blood; complications; drug therapy; Lipoproteins, LDL; blood; Male; Middle Aged; Oryza; Phytotherapy
- From: Chinese Journal of Integrated Traditional and Western Medicine 2003;23(10):750-752
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the lipid regulatory effect of Xuezhikang (XZK) and its effects on serum oxidized low density lipoprotein (OX-LDL), C-reactive protein (CRP) and fibrinogen (FIB) in patients with unstable angina pectoris (UAP).
METHODSUAP patients with hyperlipidemia were treated with XZK 0.6 g, orally taken, twice a day for 2 successive months followed by half dosage for 2 months. To UAP patients with normal blood lipids, Vit E was given orally for 4 months. Levels of blood lipids, OX-LDL, CRP, FIB at the time of entry, 1st and 2nd month of the therapeutic course were observed and end-point events in the two groups was compared.
RESULTSXZK can reduce the serum level of total cholesterol, low density lipoprotein after being administered for 1 month, and the effect further elevated after 2 months. Its effect in lowering triglycerides and increasing high density lipoprotein initiated after 2 months administration. Compared with effect of Vit E, XZK can significantly lower the serum OX-LDL, CRP and FIB after 2 months administration, and reduce the end-point events in 4 months.
CONCLUSIONXZK has good regulatory effect on blood lipids, it also can inhibit the development of inflammation in coronary plaque, therefore, is beneficial to the prognosis of UAP patients.
