Accuracy of 18F-FDG PET/CT for lymph node staging in non-small-cell lung cancers.
- Author:
Bao-jun LIU
1
;
Jing-cheng DONG
;
Chang-qing XU
;
Chuan-tao ZUO
;
Jing-Jing LE
;
Yi-hui GUAN
;
Jun ZHAO
;
Jin-feng WU
;
Xiao-hong DUAN
;
Yu-xue CAO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Carcinoma, Non-Small-Cell Lung; diagnosis; Female; Fluorodeoxyglucose F18; Humans; Lung Neoplasms; diagnosis; Lymph Nodes; pathology; Lymphatic Metastasis; diagnosis; Male; Middle Aged; Neoplasm Staging; methods; Positron-Emission Tomography; methods; Retrospective Studies
- From: Chinese Medical Journal 2009;122(15):1749-1754
- CountryChina
- Language:English
-
Abstract:
BACKGROUNDThis retrospective study evaluated the diagnostic accuracy of 2-(F18)-fluoro-2-deoxy-D-glucose-positron emission tomography ((18)F-FDG-PET)/computed tomography (PET/CT) in the preoperative diagnosis of metastatic mediastinal and hilar lymph node in patients with non-small-cell lung cancer (NSCLC).
METHODSA total of 39 patients received preoperative (18)F-FDG PET/CT and the postoperative biopsy. We compared preoperative PET/CT scan results with corresponding intraoperative histopathalogic findings in 39 NSCLC patients. The sensitivity, specificity, accuracy, positive and negative predictive value of (18)F-FDG PET/CT were assessed.
RESULTSHistopathologic examination confirmed metastasis in 57 out of the 208 excised lymph nodes; 23 of the 57 nodes were mediastinal and hilar lymph nodes. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of PET/CT in the preoperative diagnosis of mediastinal lymph node metastasis in NSCLC patients were 65%, 96.8%, 92%, 78.5% and 90%, respectively.
CONCLUSIONSPET/CT scan showed good accuracy in the preoperative diagnosis of mediastinal and hilar lymph node metastasis in the patients with NSCLC. We recommend that PET/CT scanning be used as a first-line evaluation tool for tumor diagnosis, therapy evaluation and follow-up.
