Biosynthesis-based production improvement and structure modification of erythromycin A.
- Author:
Dandan CHEN
;
Jiequn WU
;
Wen LIU
- Publication Type:Journal Article
- MeSH:
Anti-Bacterial Agents;
biosynthesis;
chemistry;
Erythromycin;
biosynthesis;
chemistry;
Glycosylation;
Hydroxylation;
Methylation;
Multigene Family;
Polyketide Synthases;
metabolism
- From:
Chinese Journal of Biotechnology
2015;31(6):939-954
- CountryChina
- Language:Chinese
-
Abstract:
Erythromycin A is a clinically important macrolide antibiotic with broad-spectrum activity. Its biosynthesis involves the formation of the 14-membered skeleton catalyzed by polyketide synthases, and the modification steps such as hydroxylation, glycosylation and methylation. Based on the understanding of the biosynthetic mechanism, it is reliable to genetically manipulate the erythromycin A-producing strain for production improvement and structure modification. In this paper, we reviewed the progress regarding erythromycin A in high-producing strain construction and chemical structure derivation, to provide insights for further development.
