Investigation of sub-clinical infection of hepatitis E virus in blood donors.
- Author:
Dong-ying GAO
1
;
Geng PENG
;
Jia-ming ZHU
;
Li SUN
;
Ying-jie ZHENG
;
Jun ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Alanine Transaminase; blood; Blood Donors; Female; Hepacivirus; immunology; Hepatitis Antibodies; blood; Hepatitis E; epidemiology; Hepatitis E virus; immunology; Humans; Immunoglobulin M; blood; Male
- From: Chinese Journal of Hepatology 2004;12(1):11-12
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo understand the prevalence of sub-clinical infection of hepatitis E virus (HEV) among blood donors.
METHODSA cluster sampling strategy was used to sample all blood donors from July to August in 2002 in Beijing. Their blood was tested for IgM and IgG antibody against HEV.
RESULTSThe prevalence of anti-HEV IgM among blood donors in Beijing was 1.74%. The rate of abnormal alanine aminotransferase (ALT) in anti-HEV IgM positive donors is significantly higher than anti-HEV IgM negative donors. Among all ALT abnormal donors, 2.68% can be associated with HEV sub-clinical infection. The percentage is similar with HBV but higher than HCV.
CONCLUSIONThere are sub-clinical infection of HEV among blood donors, which is one of the cause of abnormal ALT in the donors.
