Detection of hepatitis E virus on a blood donor and its infectivity to rhesus monkey.
- Author:
Ning-shao XIA
1
;
Jun ZHANG
;
Ying-jie ZHENG
;
Yan QIU
;
Sheng-xiang GE
;
Xiang-zhong YE
;
Shan-hai OU
Author Information
- Publication Type:Journal Article
- MeSH: Acute Disease; Animals; Blood Donors; Hepatitis E; transmission; Hepatitis E virus; isolation & purification; Humans; Macaca mulatta; RNA, Viral; blood; Transfusion Reaction
- From: Chinese Journal of Hepatology 2004;12(1):13-15
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo understand the infectivity and pathogenicity of the plasma of hepatitis E virus (HEV) viremia to primate animals.
METHODSRNA fragment of HEV genotype IV was detected on one healthy donor who was positive for anti-HEV IgM and negative for anti-HEV IgG. Then 10 ml plasma from above donor was transfused to rhesus monkey to observe its infectivity and pathogenicity.
RESULTSAcute hepatitis E was developed in rhesus monkey who accept HEV RNA positive plasma. It was confirmed by virological, immunological, biochemical and histopathological data.
CONCLUSIONAcute hepatitis E can be induced by plasma transfusion of HEV viremia, which indicate the possibility of transfusion transmitted hepatitis E
