HCV RNA in PBMC as predictor of the response to antiviral therapy in chronic hepatitis C.
- Author:
Dao-zhen XU
1
;
Zheng-qin LI
;
Yao XIE
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Female; Hepatitis C, Chronic; drug therapy; virology; Humans; Interferon-alpha; therapeutic use; Leukocytes, Mononuclear; virology; Male; Middle Aged; RNA, Viral; blood; Recombinant Proteins
- From: Chinese Journal of Hepatology 2004;12(2):76-78
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the predictive value of HCV RNA in PBMC of patients with chronic hepatitis C to IFN treatment.
METHODSThe HCV RNAs in PBMC were detected at the end of treatment, and 24 week and 1 year follow up after end treatment, in 16 patients who acquired complete response to IFN in 12 weeks of 24 weeks therapy.
RESULTS9 patients were HCV RNA positive in their PBMC at the end of treatment, the serum HCV RNA of 8 turned positive after 24 weeks and 1 year follow-up. In 7 patients with negative HCV RNA in PBMC, only two patients relapsed in serum HCV RNA after 1 year follow-up, and others remained viral response after 3.5 years.
CONCLUSIONHCV RNA in PBMC at the end of treatment was a predictor of the durable response to antiviral therapy in chronic hepatitis C.
