Differential display of homeobox gene expressions in the normal, wounded human fetal and adult skins by DNA microarray.
- Author:
Hui-Feng SONG
1
;
Jia-Ke CHAI
;
Min-Liang CHEN
;
Zi-Hao LIN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Animals; Cells, Cultured; Child; Female; Fetus; Gene Expression; Gene Expression Profiling; Genes, Homeobox; genetics; Homeodomain Proteins; genetics; Humans; Male; Mice; Mice, Inbred BALB C; Oligonucleotide Array Sequence Analysis; Skin; Wound Healing; genetics; Young Adult
- From: Chinese Journal of Plastic Surgery 2005;21(5):372-374
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the differential expression of homeobox genes in the normal, wounded human fetal and adult skins and its significance in fetal scarless healing.
METHODSGene chips containing 14 000 human genes were used to investigate homeobox gene expressions of the normal, wounded human fetal and adult skins.
RESULTSThere were significant differences between the expression of homeobox genes, especially for PRX-2, HOXB13, HOXB6 and HOXB7.
CONCLUSIONSThe homeobox gene is in close relation to developmental biology. The different expressions and changes of homeobox genes in the normal, wounded human fetal and adult skin may be a primary cause of different wound healing between fetal and adult skin.
