Expression and significance of TRAIL receptors in fibroblasts of hypertrophic scar.
- Author:
Xiang-feng LENG
1
;
De-chang WANG
;
Ran HUO
;
Qiu ZHANG
;
Wen-jun XUE
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Apoptosis; Burns; complications; metabolism; pathology; Child; Child, Preschool; Cicatrix, Hypertrophic; etiology; metabolism; pathology; Female; Fibroblasts; metabolism; Humans; Male; Receptors, TNF-Related Apoptosis-Inducing Ligand; metabolism; Young Adult
- From: Chinese Journal of Plastic Surgery 2005;21(6):444-447
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect the expression of TRAIL receptors in fibroblasts of hypertrophic scar in the proliferative stage and explore its significance.
METHODS30 samples of hypertrophic scar were taken from 30 burn cases in the proliferative stage. 30 samples of normal skin were taken as the control. The expressions of TRAIL receptors in the fibroblasts of hypertrophic burn scar and the normal skin were assayed by semiquantitative RT-PCR and flowcytometry.
RESULTSThe expression level of DR5 in the fibroblasts of hypertrophic burn scar is much lower than the control (P < 0.05); the expression level of DcR1 in the fibroblasts of hypertrophic burn scar is much higher than the control (P < 0.05).
CONCLUSIONSThe down-regulated DR5 expression and elevated DcR1 expressions in the fibroblasts of hypertrophic burn scar may attribute to the apoptosis change induced by TRAIL and explain the apoptosis differences between the fibroblasts of hypertrophic scar and normal skin to a certain extent.
