The experimental study of mechanism of integrin in hypertrophic scar contracture.
- Author:
Zheng-yu HE
1
;
Xiao-bing HOU
;
Zhi-hong FAN
Author Information
- Publication Type:Journal Article
- MeSH: Actins; biosynthesis; Adult; Cells, Cultured; Cicatrix, Hypertrophic; metabolism; pathology; Contracture; metabolism; pathology; Fibroblasts; metabolism; Focal Adhesion Kinase 1; biosynthesis; Humans; Integrins; biosynthesis; RNA, Messenger; metabolism; Young Adult
- From: Chinese Journal of Plastic Surgery 2006;22(1):38-40
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the mechanism of integrin in hypertrophic scar.
METHODSFibroblasts from 10 samples of human hypertrophic scars was cultured, FQ-PCR assay was applied to detect mRNA expression of alpha-SMA in hypertrophic scar fibroblasts after integrin and FAK antibody blocking.
RESULTSmRNA of alpha-SMA in fibroblasts expressed obviously lower after integrin and FAK antibody blocking than that of control groups ( P < 0.05).
CONCLUSIONThrough accelerating the synthesis of alpha-SMA, integrin and FAK play an important role in contracture of hypertrophic scar.
