Relationship between expression of inducible nitric oxide synthase and proliferative potency of endothelium in hemangioma in infants.
- Author:
Jin-song LI
1
;
Hai-gang LI
;
Wei-liang CHEN
;
Xuan-ling HE
;
Zhao-hui YANG
;
Hui-lin CHENG
Author Information
- Publication Type:Journal Article
- MeSH: Child, Preschool; Endothelium; metabolism; Endothelium, Vascular; cytology; Female; Hemangioma; metabolism; pathology; Humans; Hyperplasia; Infant; Ki-67 Antigen; metabolism; Male; Neovascularization, Pathologic; metabolism; Nitric Oxide Synthase Type II; metabolism
- From: Chinese Journal of Plastic Surgery 2006;22(1):49-51
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate relationship between expression of inducible nitric oxide synthase (iNOS) and proliferative potency of endothelium in hemangioma (HM).
METHODSImmunohistochemical staining was used to detect expression of iNOS and Ki-67 protein in 49 cases of HM and 29 cases of vascular malformation (VM).
RESULTSExpressive rate of iNOS and Ki-67 protein of 49 cases of HM was 38% and (10.98 +/- 7.93)%. Expressive rate of iNOS and Ki-67 protein of 29 cases of VM was respectively 3% and (0.03 +/- 0.19)%. The expressive rate of iNOS and Ki-67 protein of HM was significantly higher than that of VM (P = 0.001 and 0). The expressive rate of Ki-67 protein of HM of proliferative phase was (12.67 +/- 7.65)% , which was significantly higher than that of HM of extinctive phase, (7.27 +/- 7.49)% (P = 0.028).
CONCLUSIONSExpression of iNOS and Ki-67 protein of HM is significantly higher than that of VM, and the proliferative potency of HM is significantly higher than that of VM.
