Pharmacological action and mechanisms of ginkgolide B.
- Author:
Shi-hai XIA
1
;
Dian-chun FANG
Author Information
- Publication Type:Journal Article
- MeSH: Acute Disease; Animals; Anti-Asthmatic Agents; pharmacology; Antineoplastic Agents; pharmacology; Ginkgolides; chemistry; pharmacology; Humans; Lactones; chemistry; pharmacology; Neuroprotective Agents; pharmacology; Pancreatitis; drug therapy; Reperfusion Injury; prevention & control
- From: Chinese Medical Journal 2007;120(10):922-928
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo review the recent research progress in pharmacological actions and mechanisms of ginkgolide B. Data sources Information included in this article was identified by searching of PUBMED (1987 - 2006) online resources using the key terms "ginkgolide B", "platelet activating factor", and "pharmacological". Study selection Mainly original milestone articles and critical reviews written by major pioneer investigators of the field were selected.
RESULTSThe key issues related to the pharmacological actions and mechanisms of ginkgolide B were summarized. The ginkgolide B possesses a number of beneficial effects such as anti-inflammatory, anti-allergic, antioxidant, and neuroprotective effects. Meantime, their mechaniams were discussed.
CONCLUSIONSThe Ginkgolide B is the most potent antagonist of platelet activating factor (PAF) and exhibits therapeutic action in a variety of diseases mainly by the PAF receptor.
