Long-Term Outcomes after Cryotherapy for Conjunctival Mucosa-Associated Lymphoid Tissue Lymphomas.
10.3341/jkos.2015.56.11.1653
- Author:
Si Eun LEE
1
;
Keun Hae KIM
Author Information
1. Department of Ophthalmology, Catholic University of Daegu School of Medicine, Daegu, Korea. kimkh@cu.ac.kr
- Publication Type:Original Article
- Keywords:
Conjunctiva;
Cryotherapy;
Mucosa-associated lymphoid tissue (MALT) lymphoma
- MeSH:
Conjunctiva;
Cryotherapy*;
Diagnosis;
Follow-Up Studies;
Humans;
Lymphoid Tissue;
Lymphoma;
Lymphoma, B-Cell, Marginal Zone*;
Radiotherapy;
Recurrence;
Retrospective Studies
- From:Journal of the Korean Ophthalmological Society
2015;56(11):1653-1660
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate long-term outcomes after cryotherapy for conjunctival mucosa-associated lymphoid tissue (MALT) lymphomas. METHODS: We retrospectively analyzed 11 eyes of 8 patients who underwent cryotherapy with a confirmed histopathological diagnosis of conjunctival MALT lymphoma between January 2006 and December 2010 and were followed up for at least a year. RESULTS: The mean patient age was 36.8 years and the average follow-up was 4.1 years. Complete remission was achieved in 3 patients (4 eyes) and recurrence occurred in 5 patients (7 eyes) after the first cryotherapy. After the third cryotherapy, complete remission was achieved in 2 patients (2 eyes) and recurrence occurred in 3 patients (5 eyes). Therefore, 3 patients (5 eyes) underwent radiotherapy and finally achieved complete remission. After cryotherapy, significant complications were not observed except mild symblepharon in 4 patients (6 eyes). CONCLUSIONS: Cryotherapy, although having a higher recurrence rate than radiotherapy, is a simple treatment modality with fewer complications for patients. In the conjunctival MALT lymphoma patients who cannot undergo radiotherapy, cryotherapy should be considered as an alternative treatment modality.
