Clinical characteristics of human infection with a novel avian-origin influenza A(H10N8) virus.

Wei Zhang; Jianguo Wan; Kejian Qian; Xiaoqing Liu; Zuke Xiao; Jian Sun; Zhenguo Zeng; Qi Wang; Jinxiang Zhang; Guanghui Jiang; Cheng Nie; Rong Jiang; Chengzhi Ding; Ran LI; Peter Horby; Zhancheng Gao

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Clinical characteristics of human infection with a novel avian-origin influenza A(H10N8) virus.

Author: Wei ZHANG ¹ ; Jianguo WAN ² ; Kejian QIAN ¹ ; Xiaoqing LIU ³ ; Zuke XIAO ⁴ ; Jian SUN ⁵ ; Zhenguo ZENG ¹ ; Qi WANG ⁶ ; Jinxiang ZHANG ² ; Guanghui JIANG ² ; Cheng NIE ¹ ; Rong JIANG ¹ ; Chengzhi DING ¹ ; Ran LI ⁷ ; Peter HORBY ⁸ ; Zhancheng GAO ⁹
Author Information

1. Nanchang University First Affiliated Hospital, Nanchang, Jiangxi 330006, China.
2. Nanchang First Hospital, Nanchang, Jiangxi 330008, China.
3. Jiangxi Province Center for Disease Control and Prevention, Nanchang, Jiangxi 330038, China.
4. Jiangxi Provincial People's Hospital, Nanchang, Jiangxi 330006, China.
5. Nanchang University Fourth Affiliated Hospital, Nanchang, Jiangxi 330003, China.
6. Chinese Center for Disease Control and Prevention, Beijing 102206, China.
7. Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing 100044, China.
8. Oxford University Clinical Research Unit -Wellcome Trust Major Overseas Programme, Hanoi, Vietnam.
9. Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing 100044, China. Email: zcgao@bjmu.edu.cn.
Publication Type:Case Reports
MeSH: Aged; Antiviral Agents; therapeutic use; Female; Fluoroquinolones; therapeutic use; Humans; Imipenem; therapeutic use; Influenza A Virus, H10N8 Subtype; drug effects; pathogenicity; Influenza, Human; complications; diagnosis; drug therapy; Male; Middle Aged; Oseltamivir; therapeutic use
From: Chinese Medical Journal 2014;127(18):3238-3242
CountryChina
Language:English
Abstract:
BACKGROUNDNovel influenza A viruses of avian-origin may be the precursors of pandemic strains. This descriptive study aims to introduce a novel avian-origin influenza A (H10N8) virus which can infect humans and cause severe diseases.
METHODSCollecting clinical data of three cases of human infection with a novel reassortment avian influenza A (H10N8) virus in Nanchang, Jiangxi Province, China.
RESULTSThree cases of human infection with a new reassortment avian influenza A(H10N8) virus were described, of which two were fatal cases, and one was severe case. These cases presented with severe pneumonia that progressed to acute respiratory distress syndrome (ARDS) and intractable respiratory failure.
CONCLUSIONThis novel reassortment avian influenza A (H10N8) virus in China resulted in fatal human infections, and should be added to concerns in clinical practice.