Competing risk model based study of outcomes of mild cognitive impairment of seniors
10.3760/cma.j.issn.0254-6450.2015.03.011
- VernacularTitle:基于竞争风险模型的老年人轻度认知损害转归研究
- Author:
Qianqian SUN
1
;
Yanlong SONG
;
Panpan KONG
;
Hongmei YU
Author Information
1. 山西医科大学公共卫生学院
- Keywords:
Mild cognitive impairment;
Alzheimer's disease;
Competing risk model;
Longitudinal data
- From:
Chinese Journal of Epidemiology
2015;36(3):241-244
- CountryChina
- Language:Chinese
-
Abstract:
Objective To introduce the competing risk model into outcome prediction of mild cognitive impairment (MCI) of seniors and to explore influencing factors for the prognosis of MCI to Alzheimer' s disease (AD).Methods Data were collected from six follow-up visits to 600 seniors from communities in Taiyuan city,which were conducted at an interval of six months from October 2010 to May 2013.MCI state was defined as the transient state,AD and death before AD as two absorbing states (death before AD in which was regarded as a competing risk event),building the competing risk model to identify the model parameters,and to explore influencing factors on MCI prognosis to AD.In the meantime,the 3-year MCI-AD transition probability was estimated based on the multi-state Markov model.Results Based on screening with the multivariate competing risk model analysis,factors such as higher age (estimate HR=1.56,95％CI:1.01-2.39),female gender (HR=1.72,95％CI:1.02-2.92),higher education(HR=0.64,95％CI:0.41-1.00),reading frequently (HR=0.57,95％CI:0.32-0.99),hypertension (HR=3.43,95％CI:1.08-10.85) and high SBP(HR=1.67,95％CI:1.04-2.66),were statistically significant for transition from MCI to AD in three years.3-year MCI-AD transition probability was 10.7％(95％CI:8.6％-13.2％).Conclusion Age,gender,education,reading and blood pressure were the influencing factors for the prognosis of MCI to AD.Competing risk model was advantageous in studying longitudinal data with multiple potential outcomes.
