Association between CYP1A1 genetic polymorphisms and coronary artery disease in Uygur population in Xinjiang, China
10.3760/cma.j.issn.0254-6450.2015.04.021
- VernacularTitle:细胞色素氧化酶基因CYP1A1多态性与新疆维吾尔族人群冠心病相关性研究
- Author:
Jinguo ZOU
1
,
2
;
Yitong MA
;
Xiang XIE
;
Yining YANG
;
Fen LIU
Author Information
1. 830054乌鲁木齐,新疆医科大学第一附属医院心脏中心
2. 830054乌鲁木齐,新疆医科大学第一附属医院心血管病重点实验室
- Keywords:
Coronary artery disease;
CYP1A1;
Single nucleotide polymorphism
- From:Chinese Journal of Epidemiology
2015;36(4):393-398
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the association between human CYP1A1 gene polymorphisms and coronary artery disease (CAD) among the Uygur population of China.Methods Genotypes of CYP1A1 single nucleotide polymorphisms (SNPs:rs4886605,rs 12441817,rs4646422 and rs1048943) were detected by real-time PCR in 293 CAD patients and 408 controls.Results Among the Uygur group,distribution of genotypes and allele of rs4886605 were both significantly different between CAD and the controls (all P＜0.05).The dominant model (CC vs.CT + TT) of rs4886605 was significantly lower among CAD patients than in controls.Significant differences were retained after the adjustment was made in all the participants (OR=0.368,95％CI:0.185-0.530,P=0.018) and in men (OR=0.350,95％CI:0.235-0.568,P=0.015).Distributions of genotypes and allele of rs12441817 were both significantly different between CAD and the controls (all P＜0.05).The dominant model (TT vs.CT+CC) of rs12441817 was significantly lower among patients CAD than in controls.Significant difference were retained after the adjustment was made,in total participants (OR=0.253,95％ CI:0.231-0.546,P=0.016) and in men (OR=0.241,95％ CI:0.132-0.478,P=0.002).Conclusion Both rs4886605 and rs12441817 SNPs of the CYP1A1 gene were associated with CAD in the Uygur population of China.
