Investigation of the cutoff value of a serum 1,3-beta-D-glucan assay for early diagnosis of invasive fungal infection in Chinese hematopoietic stem cell transplant recipients.
- Author:
Yu JI
1
;
Xiao-jun HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Early Diagnosis; Female; Hematopoietic Stem Cell Transplantation; Humans; Male; Mycoses; blood; diagnosis; etiology; Postoperative Complications; blood; diagnosis; Predictive Value of Tests; Sensitivity and Specificity; beta-Glucans; blood
- From: Chinese Journal of Hematology 2008;29(6):405-407
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the significance of a serum 1,3-beta-D-glucan (BG) assay for early diagnosis of invasive fungal infection (IFI) and determine its cutoff value in Chinese post-hematopoietic stem cell transplant (HSCT) recipients.
METHODSSerum BG levels were measured twice weekly by Glucatell kit (G-Test) in 36 post-HSCT patients with suspected IFI. The sensitivities and specificities of the assay for clinical proven IFI and non-IFI patients were calculated retrospectively according to different G-Test positive criteria and determined its cutoff.
RESULTSThe sensitivity, specificity, positive and negative predictive values were 81.0%, 81.8%, 89.5% and 69.2% (P=0.002) respectively, as the cutoff value was set at more than 80 ng/L once or 60 ng/L consecutively twice.
CONCLUSIONThe cutoff value of G test in Chinese post HSCT patients basically is the same as specified in the instruction of the kit, and it is a quick and reliable method for early diagnosis of IFI.
