Expression of cyclin A in childhood acute leukemia and its significance.
- Author:
Jun WANG
1
;
Yun-juan ZHANG
;
Jian-fei FENG
;
Xi-Ge WANG
;
Cai-yan DENG
;
You-cai TANG
Author Information
- Publication Type:Journal Article
- MeSH: Acute Disease; Adolescent; Child; Child, Preschool; Cyclin A; genetics; metabolism; Female; Humans; Infant; Leukemia; metabolism; Male
- From: Chinese Journal of Hematology 2008;29(11):746-748
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of cyclin A protein in childhood acute leukemia (AL) and its significance.
METHODSBy using Western blotting analysis, cyclin A protein in bone marrow mononuclear cells from 47 newly diagnosed AL children and 33 non-hematological malignancy children was detected.
RESULTSThe expression of cyclin A in AL group (0.38 +/- 0.20) was higher than that in control group (0.03 +/- 0.15) (P < 0.01). The expression of cyclin A in high risk acute lymphocyte leukemia (ALL) group (HR-ALL) (0.62 +/- 0.38) was higher than that in standard risk ALL group (SR-ALL) (0.33 +/- 0.33) (P < 0.05). The expression of cyclin A in WBC > or = 50 x 10(9)/L group and in WBC < 50 x 10(9)/L group was (0.64 +/- 0.36) and (0.39 +/- 0.38), respectively (P < 0.05). Eight (44.4%) out of 18 patients with positive cyclin A expression achieved complete remission (CR). The CR rate was lower than that of patients with negative cyclin A expression (100%) (P < 0.01).
CONCLUSIONSThe higher expression of cyclin A may predict a poor prognosis for childhood ALL.
