Diagnostic value of FDG-PET in the detection of bone marrow involvement in patients with diffuse large B-cell lymphoma.
- Author:
Xu ZHANG
1
;
Wei FAN
;
Xiao-Ping LIN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Bone Marrow; pathology; Female; Fluorodeoxyglucose F18; Humans; Leukemic Infiltration; diagnostic imaging; Lymphoma, Large B-Cell, Diffuse; diagnostic imaging; pathology; Male; Middle Aged; Positron-Emission Tomography; methods; Young Adult
- From: Chinese Journal of Hematology 2008;29(12):832-835
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the diagnostic value of bone marrow (BM) involvement detected by F-18-fluorodeoxyglucose-positron emission tomography/computed tomography ((18)F-FDG PET/CT) in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL).
METHODSThe study population comprised 81 consecutive patients with newly diagnosed DLBCL. All patients had both (18)F-FDG PET/CT and standard BM biopsy at iliac crest. In 9 patients, additional direct BM biopsy at FDG-avid bone lesion was performed.
RESULTSAmong all 81 cases, 23 were diagnosed as BM involvement by PET/CT. Of the 23 positive cases 17 were confirmed by biopsy. However, only 11 cases were diagnosed by merely bilateral iliac crest biopsy. In patients in early stage of disease (18)F-FDG PET/CT had the same results as bilateral iliac crest biopsy.
CONCLUSION(18)F-FDG PET/CT is superior to standard BM biopsy in detecting BM involvement in newly diagnosed DLBCL patients. In patients with FDG-avid bone lesions, direct PET/CT-guided bone biopsy seems to be more accurate than standard BM biopsy.
