Comparing the actions of the three flavone ingredients in choerospondias axillaris on arrhythmias induced by aconitine.
- Author:
Feng-Hua WANG
1
;
Yu-Mei YANG
;
Ji-Hui XU
;
Jian-Min QIN
;
Kang YING
;
Chang-Zai ZHANG
;
Yi-Ting SONG
;
Teng-Fei YU
Author Information
- Publication Type:Journal Article
- MeSH: Aconitine; Anacardiaceae; chemistry; Animals; Anti-Arrhythmia Agents; isolation & purification; therapeutic use; Arrhythmias, Cardiac; chemically induced; prevention & control; Dose-Response Relationship, Drug; Female; Flavones; isolation & purification; therapeutic use; In Vitro Techniques; Male; Phytotherapy; Plants, Medicinal; chemistry; Random Allocation; Rats; Rats, Wistar
- From: China Journal of Chinese Materia Medica 2005;30(14):1096-1098
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare the actions of the three flavone ingredients in choerospondias axillaris on arrhythmias Induced by aconitine.
METHODLangendorff perfuse was applied in the experiment, the antiarrhythmic action was to study by using aconitine on the the isolated heart; The antiarrhythmic action of the three flavone ingredients in choerospondias axillaris was to study by using i.v. aconitine in rat to induce arrhythmias.
RESULTCompared with the NS group, sample 1 and sample 2 both significantly prolonged the beginning time of VF of isolated heart and increased the dosage of aconitine, sample 3 reduced the beginning time of VF of isolated heart and decreased the dosage of aconitine, sample 1 and sample 2 both greatly prolonged the beginning time of VE, VT, VF, HA; sample 3 greatly reduced the beginning time of VT,VF. The actions of the three samples were in a concentration-dependent way.
CONCLUSIONSample 1 and sample 2 both resisted the occurrence of arrhythmias induced by aconitine, sample 3 markedly promoted the occurrence of arrhythmias induced by aconitine.
