Experimental study on xue-bao capsules against injury of radiation or cyclophosphamide in mice.
- Author:
Tian-Hong GAO
1
;
Jin-Hua PIAO
;
Li ZHANG
;
Hong ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bone Marrow Cells; cytology; drug effects; radiation effects; Capsules; Cell Count; Cells, Cultured; Cyclophosphamide; toxicity; Drug Combinations; Drugs, Chinese Herbal; administration & dosage; isolation & purification; pharmacology; Erythrocyte Count; Erythroid Precursor Cells; drug effects; radiation effects; Female; Granulocyte Precursor Cells; drug effects; radiation effects; Leukocyte Count; Male; Mice; Plants, Medicinal; chemistry; Platelet Count; Radiation Injuries, Experimental; blood; pathology; Random Allocation; Whole-Body Irradiation; adverse effects
- From: China Journal of Chinese Materia Medica 2005;30(14):1102-1105
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the effects of xue-bao capsules on injury of radio-or chemo-therapy in mice, in order to provide rationale behind clinical trials.
METHODxue-xu (deficiency of blood) model in mice was induced by radiation or cyclophosphamide. Leucocyte (WBC), erythrocyte (RBC), hemoglobin (Hb) and platelet (Pt) in peripheral blood as well as CFU-E and CFU-Gm in bone marrow were counted.
RESULTCFU-E and CFU-Gm in normal mice were promoted by this drug. The reduction of WBC, RBC and Hb in peripheral blood as well as CFU-E and CFU-Gm in bone marrow owing to the 3.5 Gy of 60Co radiation were antagonized by the drug. It had also antagonized cyclophosphamide induced the reduction of WBC, RBC and Pt in peripheral blood.
CONCLUSIONxue-bao capsules has the effects against the adverse reactions of radio-or-chemo-therapy.
