Hepatoprotective effects of Gentiana scabra on the acute liver injuries in mice.
- Author:
Wei-Xin JIANG
1
;
Bao-Yu XUE
Author Information
- Publication Type:Journal Article
- MeSH: Alanine Transaminase; blood; Alkaline Phosphatase; blood; Animals; Aspartate Aminotransferases; blood; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; enzymology; etiology; Drugs, Chinese Herbal; isolation & purification; pharmacology; Female; Galactosamine; Gentiana; chemistry; Male; Mice; Plant Components, Aerial; chemistry; Plant Roots; chemistry; Plants, Medicinal; chemistry; Random Allocation; Thioacetamide
- From: China Journal of Chinese Materia Medica 2005;30(14):1105-1107
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the hepatoprotective effect of the aerial parts and the roots of G. scabra on cute liver injury models.
METHODAcute liver injury models were induced by CCl4, TAA and D-GlanN in mice, and the levels of serum enzyme ALT, AST and AKP on acute liver injury mice with extracts of theaerial parts and the roots of G. scabra were determined.
RESULTDifferent dosages of theaerial part extract could significantly reduce the levels of serum enzyme ALT, AST and AKP (P < 0.05) on CCl4 and TAA model mice, but the serum enzymes reduction of D-GlanN model mice was not remarkably.
CONCLUSIONThe methanolic extracts of the aerial parts and the roots of G. scabra both have certain hepatoprotective effects on acute liver injury models, and so the aerial parts of G. scabra can be used as the succedaneumm of G. scabra roots.
