Effects of xianggui pill on cytokine in endometriosis model rat.
- Author:
Yong-Jiu TANG
1
;
Yi CHEN
;
He-Yong YU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cell Count; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; pharmacology; Endometriosis; blood; immunology; metabolism; Female; Interleukin-8; blood; metabolism; Macrophages, Peritoneal; metabolism; pathology; Plants, Medicinal; chemistry; Random Allocation; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; metabolism
- From: China Journal of Chinese Materia Medica 2005;30(14):1108-1110
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the adjustment of Xianggui pill on the cytokine of endometriosis model rat, and investigate the mechanism of Xianggui pill on the treatment of endometriosis.
METHODTo set up endometriosis model by rat self-endometria transplantation, drench sodium chloride, Xianggui pill elixation or Danazol after grouping, and to detect the contents of interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha) by ELISA.
RESULTThe contents of IL-8, TNF-alpha in the peripheral blood and peritoneal fluid of model group were higher than that of the blank group; The quality of allotopia growth intima tissue, the quantity of macrophage in peritoneal fluid and the contents of IL-8, TNF-alpha in the Xianggui pill group and Danazol group were all lower than those of the model group; but there was no significant difference of each target between the Xianggui pill group and Danazol group.
CONCLUSIONXianggui pill can restrain significantly the growth of allotopia intima tissue, and has apparently adjustment to the cytokine.
