The solubilization effect of 2-hydroxypropyl-beta-cyclodextrin on paeonolum.
- Author:
Ling-Yan JIAN
1
;
Yue-Hui YANG
;
Ying-Hong XU
;
Zhong-Gui HE
Author Information
- Publication Type:Journal Article
- MeSH: 2-Hydroxypropyl-beta-cyclodextrin; Acetophenones; administration & dosage; chemistry; isolation & purification; Drug Stability; Excipients; Hydrogen-Ion Concentration; Paeonia; chemistry; Plants, Medicinal; chemistry; Solubility; beta-Cyclodextrins
- From: China Journal of Chinese Materia Medica 2005;30(15):1154-1156
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the solubilization effect of 2-hydroxypropyl-beta-cyclodextrin(HPCD) on paeonolum at various pH value.
METHODPhase-solubility method was adopted to study the solubilization effect at 25 degrees C and UV spectrohotometer was used to determine paeonolum content.
RESULTSThe apparent solubility of paeonolum was significantly enhanced by increased HPCD concentration. The apparent stability constant of paeonolum compounds was calculated up to 1 425 in which pH was 3 and HPCD concentration was 133.33 mmol x L(-1). The solubility of paeonolum came up to 10 mg x mL(-1).
CONCLUSIONHPCD is an ideal solubilizer for paeonolum.
