Effects of the polysaccharides isolated from ganoderma applanatum (PGA) on the level of PGE2 and gastric mucosal blood flow (GMBF) and gastric mucus secretion of rats with gastric mucosa injury.
- Author:
Ming YANG
1
;
Hong SUN
;
De-Wei YU
;
Zhi-Yong CUI
;
Jie TIAN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Anti-Ulcer Agents; administration & dosage; isolation & purification; pharmacology; Dinoprostone; metabolism; Dose-Response Relationship, Drug; Female; Ganoderma; chemistry; Gastric Mucosa; blood supply; metabolism; secretion; Male; Mucus; secretion; Polysaccharides; administration & dosage; isolation & purification; pharmacology; Rats; Rats, Wistar; Regional Blood Flow; drug effects; Stomach Ulcer; metabolism
- From: China Journal of Chinese Materia Medica 2005;30(15):1176-1178
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the protective effects of the polysaccharides isolated from ganoderma applanatum (PGA) on gastric mucosal injury in rats and the underlying mechanism.
METHODGastric ulcer was induced by either acetic acid or pylorus ligation in the rats. The level of PGE2 and GMBF, and gastric mucus secretion were examined respectively.
RESULTAfter oral administration of PGA (250-1000 mg x kg(-1)) repeatedly, the level of PGE2 and GMBF were obviously increased in gastric mucosa of rats as compared with the model group. The secretions of both free mucus in stomach and mucus of gastric wall were enhanced apparently by PGA in a dose-dependent manner.
CONCLUSIONPGA could strengthen gastric mucosa barrier by improving the level of PGE2, GMBF and the secretion of gastric mucus, which may be one of the mechanisms underlying the protective effect of PGA on the gastric mucosa during the gastric ulcer.
