Methodological studies on selectively removing toxins in Aristolochiae manshuriensis by chinese processing techniques.
- Author:
Zhi-min WANG
1
;
Li-shuang YOU
;
Xu JIANG
;
Lin LI
;
Wei-hao WANG
;
Guan WANG
Author Information
- Publication Type:Journal Article
- MeSH: Acetic Acid; Aristolochia; chemistry; Aristolochic Acids; analysis; Hot Temperature; Pharmaceutical Solutions; chemistry; Plant Stems; chemistry; Plants, Medicinal; chemistry; Sodium Bicarbonate; Technology, Pharmaceutical; methods; Temperature
- From: China Journal of Chinese Materia Medica 2005;30(16):1243-1246
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the possibility of selectively detoxifying aristolochic acids in Aristolochiae manshuriensis (Guanmutong) by the chemical properties of aristolochic acids and traditional Chinese processing experience.
METHODThe technical parameters in processing technique of A. manshuriensis were optimized by orthogonal designed methods with aristolochic acid A.
RESULTThe processing technique was soaked in 0.1 mol x L(-1) baking soda for several times and then processing with vinegar. Temperature was important factor to detoxify aristolochic acids. aristolochic acid A were removed over 90% from A. manshuriensis in laboratory and over 80% in medium-scale production by 10 batches from two origins of botanical drugs with different contents, and decreased to 0.35-0.60 mg x g(-1) in processed products. aristolochic acid A existed mostly salt-forms in the botanical drug.
CONCLUSIONMost toxic components in Guanmutong could be removed by the new processing method.
