Studies on hyaluronic acid as dendifier in Shuanghuanglian eye-drops.
- Author:
Man-ling MA
1
;
Lu LIU
;
Shu-ying SUN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Anti-Bacterial Agents; administration & dosage; isolation & purification; Drug Carriers; Drug Combinations; Drugs, Chinese Herbal; administration & dosage; isolation & purification; Eye; drug effects; Female; Hyaluronic Acid; pharmacology; toxicity; Hydrogen-Ion Concentration; Male; Ophthalmic Solutions; administration & dosage; isolation & purification; Plants, Medicinal; chemistry; Rabbits; Temperature; Viscosity; drug effects
- From: China Journal of Chinese Materia Medica 2005;30(16):1246-1248
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the possibility of hyaluronic acid as densifier of Shuanguangliao eye-drops.
METHODThe factors related with hyaluronic acid s viscosity, such as pH-value and storing temperature, are tested in this experiment. At the same time, we checked the stimulation, stability of the densifier.
RESULTThere was not effect on viscosity of pH-value and storing temperature. No stimulation on the eye was found after densified with hyaluronic acid. The viscosity properties of hyaluronic acid are stablile.
CONCLUSIONThe hyaliuronic acid added to Shuanghuanglian eye-drops are stabiliable and it can be applied in eye-drops. The increased viscosity is benefit to extend the residence time of drug in eye.
