The preparation of arabinogalactan and the mechanism of release.
- Author:
Jin-ming LI
1
Author Information
- Publication Type:Journal Article
- MeSH: Dimethylpolysiloxanes; Drug Carriers; Drugs, Chinese Herbal; administration & dosage; isolation & purification; Galactans; administration & dosage; isolation & purification; Larix; chemistry; Plants, Medicinal; chemistry; Polyethylene Glycols; Solubility; Technology, Pharmaceutical; methods; Temperature
- From: China Journal of Chinese Materia Medica 2005;30(16):1249-1251
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThe study is the research on the preparation of arabinogalactan (AG) dropping pills and the releasing mechanism.
METHODUse the orthogonal test to find out the best way to produce and advance the preparation of AG dropping pills, analysis according to the chart and DSC to find the releasing mechanism.
RESULTThe best preparation conditions are: the liquid of AG is at 75 degrees C, the temperature above the polydimethls iloxane is 30 degrees C, the distance to the frizzed liquid is 6 cm, the speed of the liquid is 30 drop x min(-1). The chart and DSC suggest: The solid disoperation of AG-PREG 4000 the complex is in a certain form which made the melting point decreased obviously, so as to increase the solution of the medicine in carrier to increase the releasing speed.
CONCLUSIONThe best preparation is reasonable, AG and carrier become a form, the melting point is low, it can release fast.
