Effect of Shuanghuang Shengbai granule on radiotherapy or chemotherapy induced leukopenia in mice.
- Author:
Yun-hui SHEN
1
;
Chang-xun CHEN
;
Zhen-ye XU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bone Marrow; ultrastructure; Bone Marrow Cells; drug effects; pathology; radiation effects; Cell Count; Cesium Radioisotopes; Cyclophosphamide; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; pharmacology; Erythrocyte Count; Granulocytes; drug effects; pathology; radiation effects; Leukocyte Count; Leukopenia; chemically induced; pathology; Male; Mice; Mice, Inbred ICR; Plants, Medicinal; chemistry; Random Allocation; Stem Cells; drug effects; pathology; radiation effects; Whole-Body Irradiation
- From: China Journal of Chinese Materia Medica 2005;30(16):1275-1279
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of Shuanghuang Shengbai granule on mice leukopenia induced by ip cyclophosphamide (CTX) or radiation.
METHODMice leukopenia models were induced by ip CTX or radiation, and then treated with Shuanghuang Shengbai granule per oral. The peripheral hemogram, thymus index, spleen index, bone marrow nucleated cell (BMNC) and colony forming unit-spleen (CFU-S) were detected. The bone marrow cell differentiation was examined. The pathological slices of bone marrow were observed.
RESULTShuanghuang Shengbai granule could increase the WBC, BMNC, CFU-S of model mice significantly; Shuanghuang Shengbai granule could make the granulocyte and erythrocyte index recovered to normal level and it could also protect the bone marrow hemotopoietic microenvironment from the harm of radiation.
CONCLUSIONShuanghuang Shengbai granule has apparent leukogenic function.
