Solubilization on cryptotanshinone by hydroxypropyl-beta-cyclodextrin and preparation of their inclusion compound.
- Author:
Xin LUO
1
;
Yue-hong XU
;
Bao CHEN
;
Lian-quan GU
;
Min HUANG
;
Pei-qing LIU
Author Information
- Publication Type:Journal Article
- MeSH: 2-Hydroxypropyl-beta-cyclodextrin; Biological Availability; Drug Carriers; Drugs, Chinese Herbal; chemistry; Phenanthrenes; chemistry; isolation & purification; Salvia miltiorrhiza; chemistry; Solubility; Technology, Pharmaceutical; methods; Time Factors; beta-Cyclodextrins; chemistry
- From: China Journal of Chinese Materia Medica 2005;30(17):1328-1331
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare cryptotanshinone (CT)-cyclodextrin inclusion compound and improve dissolution of CT.
METHODInclusion ratio was determined by plotting the phase solubility curve of CT versus hydroxypropyl-beta-cyclodextrin (HPCD). CT-cyclodextrin inclusion compound was made by wet grinding method. Properties of the inclusion compound was investigated by in vitro dissolution test, DTA and IR spectrum.
RESULTInclusion ratio of CT versus HPCD was 1:1. Dissolution of CT-HPCD inclusion compound at 45 min was 21.6 times of material drug.
CONCLUSIONDissolution of CT was improved remarkably in CT-HPCD inclusion compound. The complexation force of the inclusion compound was hydrogen bond formed by carbonyl group of CT and hydroxyl group of HPCD.
