Studies on immunoregulation of polysaccharides-la from Radix Cynanchi Bungei.
- Author:
Li-jun GAO
1
;
Jian-hua WANG
;
Jian-hua CUI
;
Han-zhong WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adjuvants, Immunologic; pharmacology; Animals; Cynanchum; chemistry; Drugs, Chinese Herbal; chemistry; pharmacology; Female; Lymphocyte Activation; drug effects; Male; Mice; Plant Roots; chemistry; Polysaccharides; isolation & purification; pharmacology; Rabbits; Random Allocation; T-Lymphocytes; drug effects; immunology
- From: China Journal of Chinese Materia Medica 2005;30(17):1352-1355
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects of PRCB1a (one component of polysaccharides from Radix Cynanchi Bungei) on transformation of T lymphocytes of rabbit in vitro and immune function in mice.
METHODThree doses of PRCB1a (2,4,6 g x L(-1)) were respectively put in bottle with PHA and blood of rabbit. The effect of PRCB1a on immunity in vitro was studied by observing transformation of T lymphocytes; The dosage of PRCB1a (50,100,150 mg x kg(-1) x d(-1)) was given orally for seven days. The effects on immune function were investigated in mice.
RESULTThree doses of PRCB1a could significantly promote (P < 0.01) the ability of T lymphocytes proliferation; PRCB1a could improve the mouse thymus and spleen index, the celiac macrophage ability of engulfing CRBC, the delayed type hypersensitivity ability and the macrophage engulfing carbon granula ability.
CONCLUSIONThe results indicate PRCB1a can enhance nonspectific and specific cellular immune function.
