Study on the anticancer activities of the Clematis manshrica saponins in vivo.
- Author:
Ying ZHAO
1
;
Chun-Mei WANG
;
Bao-Gui WANG
;
Chong-Xi ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antineoplastic Agents, Phytogenic; administration & dosage; isolation & purification; pharmacology; Cell Line, Tumor; Clematis; chemistry; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; administration & dosage; isolation & purification; pharmacology; Female; Leukemia P388; pathology; Liver Neoplasms; pathology; Male; Mice; Neoplasm Transplantation; Plant Roots; chemistry; Plants, Medicinal; chemistry; Random Allocation; Saponins; administration & dosage; isolation & purification; pharmacology; Sarcoma 180; pathology
- From: China Journal of Chinese Materia Medica 2005;30(18):1452-1453
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the anticancer activity of the Clematis manshrica saponins in vivo.
METHODAnticancer activities were tested in mice with experimental tumor (S180, HepA and P388) in vivo.
RESULTThe Clematis manshrica saponins showed a significant anticancer activities on Sarcoma-180, HepA and P388 implanted in mice. In S180 sarcoma, the average tumor inhibition rates were 42.78%, 52.06% and 58.25% (P < 0.05-0.01) respectively; The mean inhibition rates were 37.44%, 52.05% and 59.36% (P < 0.05-0.001) in Hep A tumor separately; while in P388 tumor, the mean inhibition rates were 34.50%, 46.78% and 54.39% (P < 0.05-0.01), respectively.
CONCLUSIONThe results indicate that Clematis manshrica has obvious antitumor effects against various transplanted tumor in mice.
