Effect on pharmacokinetics of pseudo-ephedrine in human plasma among herbs in Mahuang decoction.
- Author:
Feng HE
1
;
Jia-Bo LUO
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Oral; Adult; Area Under Curve; Cinnamomum; chemistry; Drug Combinations; Drug Interactions; Drugs, Chinese Herbal; administration & dosage; isolation & purification; pharmacokinetics; Ephedra; chemistry; Ephedrine; isolation & purification; pharmacokinetics; Glycyrrhiza uralensis; chemistry; Humans; Male; Plants, Medicinal; chemistry; Prunus; chemistry; Random Allocation
- From: China Journal of Chinese Materia Medica 2005;30(18):1454-1457
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo develop a GC-MS method for the determination of pseudo-ephedrine in human plasma and study the mutative rules of the pharmacokinetic parameters of the pseudo-ephedrine in different compositions.
METHODOrthogonal design was used to determine 8 compositions from Mahuang decoction (MHD). The healthy volunteers were divided into groups in random, each group including 8 men. After taking the medicine orally, vena blood would be taken out at different time. Determining pseudo-ephedrine in plasma and plotting the concentration-time curve, the pharmacokinetic parameters of each composition were calculated by WinNonlin 4.0.1. The statistical analysis of the pharmacokinetic parameters was proceeded by SPSS 10.0.
RESULTAll concentration-time curves were adequately modeled by one compartment, first order absorption model, no lag time. Some parameters of pseudo-ephedrine showed significant variance (P < 0.05) in different compositions. The statistic results showed interactions between drugs in MHD (P < 0.05).
CONCLUSIONThe other herbs erds of MHD have some certain extent effects to the pharmacokinetic parameters of pseudo-ephedrine in the dominant drug.
